Virginia Tech® home

HNFE 5184: Advanced Macronutrient Metabolism

Concentration: Applied Nutrition and Physical Activity
Credits: 3 graduate credit(s)


Macronutrients sources, interrelationships, and factors affecting utilization, metabolism, physiological, and biochemical function to provide energy. Dietary carbohydrate (simple and complex), fat, and protein metabolism following a meal, during fasting conditions, and during and after exercise or physical activity, for energy generation. Altered metabolism of dietary carbohydrates, fats, proteins, and alcohol in metabolic diseases including obesity and diabetes.

Learning Objectives

Having successfully completed this course, the student will be able to:

  • Analyze how the principles of human anatomy and physiology, and biochemistry apply to the metabolism of dietary macronutrients.
  • Classify the principal energy systems of the body and how they function at rest and during exercise to maintain energy balance.
  • Examine the major physiological and biochemical functions of macronutrients in the body in both a fed and fasted state.
  • Explain the principles of physiology in understanding digestion, absorption, transportation, and utilization of macronutrients in a fed state, and the use of stored nutrients in a fasted state in multiple organ systems (e.g.  liver, intestines, skeletal muscle, kidneys, and pancreas).
  • Discriminate between the interrelationships between the major macronutrients and their roles in metabolic flexibility and inflexibility.
  • Examine the changes to whole-body metabolism during different types of exercise.
  • Evaluate energy metabolism of macronutrients, their interrelationships with each other and with the micronutrients in a typical western diet.
  • Demonstrate development of nutrition recommendations for athletes of various types and with different goals.
  • Identify and recommend the most appropriate nutritional strategies for weight loss or weight gain based on the athlete’s physical condition and performance goals
  • Apply the principles and knowledge of sports nutrition to assess the diet, energy expenditure, and body composition of an athlete.
  • Utilize current nutrition recommendations and research-based evidence to design dietary strategies to meet health and performance goals of athletes.  

Prerequisites and Corequisites

Graduate Standing


Angela Anderson